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Accelerated tumor formation, susceptibility to(ACTFS)

MedGen UID:
482320
Concept ID:
C3280690
Finding
Synonym: ACTFS
 
Gene (location): MDM2 (12q15)
 
OMIM®: 614401

Professional guidelines

PubMed

Xu C, Zhang L, Xu S, Wang Z, Han Q, Lv Y, Wang X, Zhang X, Zhang Q, Zhang Y, He S, Yuan Q, Bian Y, Li C, Wang J, Xu F, Cao Y, Pang J, Chen Y
Cell Mol Immunol 2024 May;21(5):510-526. Epub 2024 Mar 12 doi: 10.1038/s41423-024-01146-w. PMID: 38472357Free PMC Article
Wang Y, Wang C, Guan X, Ma Y, Zhang S, Li F, Yin Y, Sun Z, Chen X, Yin H
Adv Sci (Weinh) 2023 Dec;10(36):e2303812. Epub 2023 Nov 16 doi: 10.1002/advs.202303812. PMID: 37973560Free PMC Article
Eksteen B
Clin Liver Dis 2016 Feb;20(1):1-14. Epub 2015 Sep 26 doi: 10.1016/j.cld.2015.08.012. PMID: 26593287

Recent clinical studies

Etiology

He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M
J Hepatol 2023 Aug;79(2):362-377. Epub 2023 Mar 28 doi: 10.1016/j.jhep.2023.03.016. PMID: 36996941Free PMC Article
Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, Kazmi N, Robinson TM, Albanes D, Aleksandrova K, Berndt SI, Timothy Bishop D, Brenner H, Buchanan DD, Bueno-de-Mesquita B, Campbell PT, Castellví-Bel S, Chan AT, Chang-Claude J, Ellingjord-Dale M, Figueiredo JC, Gallinger SJ, Giles GG, Giovannucci E, Gruber SB, Gsur A, Hampe J, Hampel H, Harlid S, Harrison TA, Hoffmeister M, Hopper JL, Hsu L, María Huerta J, Huyghe JR, Jenkins MA, Keku TO, Kühn T, La Vecchia C, Le Marchand L, Li CI, Li L, Lindblom A, Lindor NM, Lynch B, Markowitz SD, Masala G, May AM, Milne R, Monninkhof E, Moreno L, Moreno V, Newcomb PA, Offit K, Perduca V, Pharoah PDP, Platz EA, Potter JD, Rennert G, Riboli E, Sánchez MJ, Schmit SL, Schoen RE, Severi G, Sieri S, Slattery ML, Song M, Tangen CM, Thibodeau SN, Travis RC, Trichopoulou A, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Vodicka P, White E, Wolk A, Woods MO, Wu AH, Peters U, Gunter MJ, Murphy N
Nat Commun 2020 Jan 30;11(1):597. doi: 10.1038/s41467-020-14389-8. PMID: 32001714Free PMC Article
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Deng Q, Hu H, Yu X, Liu S, Wang L, Chen W, Zhang C, Zeng Z, Cao Y, Xu-Monette ZY, Li L, Zhang M, Rosenfeld S, Bao S, Hsi E, Young KH, Lu Z, Li Y
Nat Commun 2019 Nov 7;10(1):5061. doi: 10.1038/s41467-019-13002-x. PMID: 31699989Free PMC Article
Biggar RJ
Clin Cancer Res 2012 Apr 15;18(8):2133-7. Epub 2012 Feb 24 doi: 10.1158/1078-0432.CCR-11-1389. PMID: 22368159

Diagnosis

Wei H, Li W, Zeng L, Ding N, Li K, Yu H, Jiang F, Yin H, Xia Y, Deng C, Cai N, Chen X, Gu L, Chen H, Zhang F, He Y, Li J, Zhang C
Mol Cancer 2024 Jun 7;23(1):124. doi: 10.1186/s12943-024-02016-9. PMID: 38849840Free PMC Article
Miyano M, Sayaman RW, Shalabi SF, Senapati P, Lopez JC, Angarola BL, Hinz S, Zirbes A, Anczukow O, Yee LD, Sedrak MS, Stampfer MR, Seewaldt VL, LaBarge MA
Cancer Prev Res (Phila) 2021 Aug;14(8):779-794. Epub 2021 Jun 17 doi: 10.1158/1940-6207.CAPR-20-0635. PMID: 34140348Free PMC Article
Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, Kazmi N, Robinson TM, Albanes D, Aleksandrova K, Berndt SI, Timothy Bishop D, Brenner H, Buchanan DD, Bueno-de-Mesquita B, Campbell PT, Castellví-Bel S, Chan AT, Chang-Claude J, Ellingjord-Dale M, Figueiredo JC, Gallinger SJ, Giles GG, Giovannucci E, Gruber SB, Gsur A, Hampe J, Hampel H, Harlid S, Harrison TA, Hoffmeister M, Hopper JL, Hsu L, María Huerta J, Huyghe JR, Jenkins MA, Keku TO, Kühn T, La Vecchia C, Le Marchand L, Li CI, Li L, Lindblom A, Lindor NM, Lynch B, Markowitz SD, Masala G, May AM, Milne R, Monninkhof E, Moreno L, Moreno V, Newcomb PA, Offit K, Perduca V, Pharoah PDP, Platz EA, Potter JD, Rennert G, Riboli E, Sánchez MJ, Schmit SL, Schoen RE, Severi G, Sieri S, Slattery ML, Song M, Tangen CM, Thibodeau SN, Travis RC, Trichopoulou A, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Vodicka P, White E, Wolk A, Woods MO, Wu AH, Peters U, Gunter MJ, Murphy N
Nat Commun 2020 Jan 30;11(1):597. doi: 10.1038/s41467-020-14389-8. PMID: 32001714Free PMC Article
Konstantoulas CJ, Hagen B, Indik S
J Gen Virol 2017 Sep;98(9):2362-2367. Epub 2017 Aug 18 doi: 10.1099/jgv.0.000897. PMID: 28809145
Biggar RJ
Clin Cancer Res 2012 Apr 15;18(8):2133-7. Epub 2012 Feb 24 doi: 10.1158/1078-0432.CCR-11-1389. PMID: 22368159

Therapy

Bai Z, Zhou Y, Ye Z, Xiong J, Lan H, Wang F
Front Immunol 2021;12:808964. Epub 2022 Jan 14 doi: 10.3389/fimmu.2021.808964. PMID: 35095898Free PMC Article
Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, Kazmi N, Robinson TM, Albanes D, Aleksandrova K, Berndt SI, Timothy Bishop D, Brenner H, Buchanan DD, Bueno-de-Mesquita B, Campbell PT, Castellví-Bel S, Chan AT, Chang-Claude J, Ellingjord-Dale M, Figueiredo JC, Gallinger SJ, Giles GG, Giovannucci E, Gruber SB, Gsur A, Hampe J, Hampel H, Harlid S, Harrison TA, Hoffmeister M, Hopper JL, Hsu L, María Huerta J, Huyghe JR, Jenkins MA, Keku TO, Kühn T, La Vecchia C, Le Marchand L, Li CI, Li L, Lindblom A, Lindor NM, Lynch B, Markowitz SD, Masala G, May AM, Milne R, Monninkhof E, Moreno L, Moreno V, Newcomb PA, Offit K, Perduca V, Pharoah PDP, Platz EA, Potter JD, Rennert G, Riboli E, Sánchez MJ, Schmit SL, Schoen RE, Severi G, Sieri S, Slattery ML, Song M, Tangen CM, Thibodeau SN, Travis RC, Trichopoulou A, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Vodicka P, White E, Wolk A, Woods MO, Wu AH, Peters U, Gunter MJ, Murphy N
Nat Commun 2020 Jan 30;11(1):597. doi: 10.1038/s41467-020-14389-8. PMID: 32001714Free PMC Article
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Nogueira V, Hay N
Clin Cancer Res 2013 Aug 15;19(16):4309-14. Epub 2013 May 29 doi: 10.1158/1078-0432.CCR-12-1424. PMID: 23719265Free PMC Article
Biggar RJ
Clin Cancer Res 2012 Apr 15;18(8):2133-7. Epub 2012 Feb 24 doi: 10.1158/1078-0432.CCR-11-1389. PMID: 22368159

Prognosis

Bai Z, Zhou Y, Ye Z, Xiong J, Lan H, Wang F
Front Immunol 2021;12:808964. Epub 2022 Jan 14 doi: 10.3389/fimmu.2021.808964. PMID: 35095898Free PMC Article
Miyano M, Sayaman RW, Shalabi SF, Senapati P, Lopez JC, Angarola BL, Hinz S, Zirbes A, Anczukow O, Yee LD, Sedrak MS, Stampfer MR, Seewaldt VL, LaBarge MA
Cancer Prev Res (Phila) 2021 Aug;14(8):779-794. Epub 2021 Jun 17 doi: 10.1158/1940-6207.CAPR-20-0635. PMID: 34140348Free PMC Article
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Levine ME, Hosgood HD, Chen B, Absher D, Assimes T, Horvath S
Aging (Albany NY) 2015 Sep;7(9):690-700. doi: 10.18632/aging.100809. PMID: 26411804Free PMC Article
Fu YP, Kohaar I, Moore LE, Lenz P, Figueroa JD, Tang W, Porter-Gill P, Chatterjee N, Scott-Johnson A, Garcia-Closas M, Muchmore B, Baris D, Paquin A, Ylaya K, Schwenn M, Apolo AB, Karagas MR, Tarway M, Johnson A, Mumy A, Schned A, Guedez L, Jones MA, Kida M, Hosain GM, Malats N, Kogevinas M, Tardon A, Serra C, Carrato A, Garcia-Closas R, Lloreta J, Wu X, Purdue M, Andriole GL Jr, Grubb RL 3rd, Black A, Landi MT, Caporaso NE, Vineis P, Siddiq A, Bueno-de-Mesquita HB, Trichopoulos D, Ljungberg B, Severi G, Weiderpass E, Krogh V, Dorronsoro M, Travis RC, Tjønneland A, Brennan P, Chang-Claude J, Riboli E, Prescott J, Chen C, De Vivo I, Govannucci E, Hunter D, Kraft P, Lindstrom S, Gapstur SM, Jacobs EJ, Diver WR, Albanes D, Weinstein SJ, Virtamo J, Kooperberg C, Hohensee C, Rodabough RJ, Cortessis VK, Conti DV, Gago-Dominguez M, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Haiman CA, Cussenot O, Cancel-Tassin G, Roupret M, Comperat E, Porru S, Carta A, Pavanello S, Arici C, Mastrangelo G, Grossman HB, Wang Z, Deng X, Chung CC, Hutchinson A, Burdette L, Wheeler W, Fraumeni J Jr, Chanock SJ, Hewitt SM, Silverman DT, Rothman N, Prokunina-Olsson L
Cancer Res 2014 Oct 15;74(20):5808-18. doi: 10.1158/0008-5472.CAN-14-1531. PMID: 25320178Free PMC Article

Clinical prediction guides

Miyano M, Sayaman RW, Shalabi SF, Senapati P, Lopez JC, Angarola BL, Hinz S, Zirbes A, Anczukow O, Yee LD, Sedrak MS, Stampfer MR, Seewaldt VL, LaBarge MA
Cancer Prev Res (Phila) 2021 Aug;14(8):779-794. Epub 2021 Jun 17 doi: 10.1158/1940-6207.CAPR-20-0635. PMID: 34140348Free PMC Article
Rebouissou S, Nault JC
J Hepatol 2020 Feb;72(2):215-229. doi: 10.1016/j.jhep.2019.08.017. PMID: 31954487
Deng Q, Hu H, Yu X, Liu S, Wang L, Chen W, Zhang C, Zeng Z, Cao Y, Xu-Monette ZY, Li L, Zhang M, Rosenfeld S, Bao S, Hsi E, Young KH, Lu Z, Li Y
Nat Commun 2019 Nov 7;10(1):5061. doi: 10.1038/s41467-019-13002-x. PMID: 31699989Free PMC Article
Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA
Cell Stem Cell 2019 Sep 5;25(3):433-446.e7. Epub 2019 Jun 13 doi: 10.1016/j.stem.2019.05.013. PMID: 31204176Free PMC Article
Guo HB, Liu F, Chen HL
Biochem Biophys Res Commun 1999 Oct 22;264(2):509-17. doi: 10.1006/bbrc.1999.1303. PMID: 10529394

Recent systematic reviews

Song Y, Qi X, Liu X
Gene 2020 Oct 5;757:144924. Epub 2020 Jul 2 doi: 10.1016/j.gene.2020.144924. PMID: 32622992
Gaba F, Manchanda R
Best Pract Res Clin Obstet Gynaecol 2020 May;65:46-65. Epub 2020 Feb 4 doi: 10.1016/j.bpobgyn.2020.01.006. PMID: 32192936
Quarles CC, Bell LC, Stokes AM
Neuroimage 2019 Feb 15;187:32-55. Epub 2018 May 3 doi: 10.1016/j.neuroimage.2018.04.069. PMID: 29729392Free PMC Article

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    Clinical resources

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